ISSN 1662-4009 (online)

ey0020.4-4 | Novel Players in the Pathogenesis of DSD | ESPEYB20

4.4. Elevated plasma miR-210 expression is associated with atypical genitalia in patients with 46,XY differences in sex development

FM Elias , MY Nishi , MHP Sircili , RL Bastista , NL Gomes , MTM Ferrari , EMF Costa , FT Denes , BB Mendonca , S Domenice

Brief summary: This translational study showed an increased plasma expression of miR-210 in individuals with 46,XY DSD compared to the control population and also showed a positive association between the presence of atypical genitalia and plasma levels of miR-210 expression in individuals with 46,XY DSD. The findings of this study contribute to a novel perspective on the possible role of miRNAs in the development of the male external genitalia and in the development of phenot...